Can we stop aging? | Andrei Gudkov | TEDxMorristown

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5 yıl önce

Scientist and expert Dr. Andrei Gudkov tells us what aging really is, how and why it happens, and what our future might be. What is the key to longer, healthier lives, and is it in our reach?

Andrei is a preeminent cancer researcher, Senior Vice President for Basic Science; Chair of the Department of Cell Stress Biology, and a member of the senior leadership team for National Cancer Institute (NCI) Cancer Center Support Grant at Roswell Park Cancer Institute (RPCI). He is responsible for building on the basic and translational research strengths of the Cell Stress Biology program in DNA damage and repair, photodynamic therapy, thermal and hypoxic stress and immune modulation. Andrei was formerly at the Lerner Research Institute, Cleveland Clinic Foundation, where he served as Chair of the Department of Molecular Genetics and professor of biochemistry at Case Western Reserve University. He earned his doctoral degree in Experimental Oncology at the Cancer Research Center, USSR and a Doctorate of Science (D.Sci) in Molecular Biology at the Moscow State University, USSR. He has authored or co-authored 218 scientific articles, holds 54 patents and co-founded six biotech companies, including Everon Biosciences, Inc. that develops antiaging drugs.

This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at

Luna M.
Luna M. 4 yıl önce
I love this presentation! Smart and with a great sense of humour!
Galt Barber
Galt Barber 4 yıl önce
If he is right (and I doubt it is so simple) then using genome editing tools to remove endogenous viruses in our junk dna would greatly expand the lifespan of many creatures.
Rhyothemis princeps
Rhyothemis princeps 3 yıl önce
@chang jeffrey I've searched for papers that support the claim the endogenous retrovirus activation is responsible for the induction of cellular senescence but have not found any. If you have citations, please list them.
chang jeffrey
chang jeffrey 3 yıl önce
Galt Barber there’re actually a lot of research papers supporting his claim. Obvious you can’t get eternal life from just doing this, but expand it 20 percent is actually possible. There’re other issue such as lack of NAD+ and stem cell we also need to deal with but we are definitely on the right track.
faismasterx 4 yıl önce
Dieter is right. Invading the genome and abruptly lacerating huge parts of the code may very likely (with a high degree of probability) have unforeseen consequences in normal functions in a way that might have the opposite intended effect. The converse is also likely to be the case wrt gene editing in fully grown organisms. Gene sequences aren't lego blocks. Though, sometimes I wish they worked that way.
Victor Jaravine
Victor Jaravine 4 yıl önce
how about accumulation of mutations in DNA repairing genes (due to radiation etc.)? some estimates put this mutation rate at 1 / 25 years, ( or 4 per 100 years, which is estimated to be lethal)
Dieter Buys
Dieter Buys 4 yıl önce
Yeah but this accounts for such a huge proportion of our DNA and so much of it is profoundly entangled with actual working systems of the body. It's not like you can just delete 8% or more of a complex mammal's DNA and expect good results, although perhaps in the end game we will be able to break these viruses permanently through rearranging their DNA to something harmless in humans.
John Kopf
John Kopf 2 yıl önce
I like the ideas shared. It does seem like the start of of a scary movie where they wake up something in our DNA and it spreads.
City Plan
City Plan 8 aylar önce
excelente presentacion, acabar con el envejecimiento es el foco , el mayor logro de la humanidad!!
Rose Calderon
Rose Calderon 2 yıl önce
This TEDTalk reached so many pathways of mind stemulation.. Genius Talks Ted👍😃
Irina Gadolina
Irina Gadolina 5 yıl önce
Thank you dear lector!
Quinn Jones
Quinn Jones Yıl önce
Amazing what can happen when enterprising students have access to research grants ... \
darren dwyer
darren dwyer 4 yıl önce
82,000 dna extractions or executions means 3420 or so dna extractions per hour, which means about 57 extractions per minute.... or approximately one protein sequence interpreted each second... by extractions, I mean, dna is encoded and is submitted to the ribosome which creates proteins based on the instructions in the dna. maybe people could think about this more.
darren dwyer
darren dwyer 4 yıl önce
what happens if you imagine dna is like a ticker-tape, being fed incrementally into the ribosome to create 10,000 or more protein types each day.... maybe this ticker-tape of dna is fixed length, say, 100 years or so, and then the ticker-tape simply runs out of code? what would happen if you extended the length of dna?
chris silliker
chris silliker 6 aylar önce
There is a cap on our dna called the telomere cap
Carole Devlin
Carole Devlin 2 yıl önce
I am time traveling. I started in 1960. From my experience, our vision is going to improve January 1. We will all see 2020!
ElementofPower Yıl önce
Thanks for Jinxing it.
Ben Gil
Ben Gil 2 yıl önce
farfett_il-lejl 😂😂😂
farfett_il-lejl 2 yıl önce
This comment did not age well
Jacob Abrams
Jacob Abrams 3 yıl önce
Doesn't telomere shortening lead to DNA damage which leads to cell senescence?
Anime Enjoyer
Anime Enjoyer 11 aylar önce
Maybe we should think of a different methode to reduce H2O2 production in our system.
Arthur Almeida
Arthur Almeida 2 yıl önce
Senescence can be induced in differents ways
Adriana Palumbo
Adriana Palumbo 2 yıl önce
That's what I was taught.
R K 10 aylar önce
Watched all of it, great news and video
Vulcan Princess
Vulcan Princess 2 yıl önce
in other words how can we call ourselves so civilized when we're still losing battles to microscopic "non-intelligent" organisms
My Ears Got Youth System
My Ears Got Youth System 2 yıl önce
@Cur Tseed unfortunately it wasn't a priority.
Cur Tseed
Cur Tseed 2 yıl önce
Most humans want to dominate other others human they see beneath them since that has proven to be simple compared to past civilizations. The unknown is not worth their time even if that means death will come knocking. If we were really serious about stopping ageing or slowing it down so that our brains match our bodies we will make it an institution to stimulate all minds to contribute to the cure. Until then everybody will just be in denial like everybody else until they die and rinse & repeat. We are the laughing stick of the universe.
Oslo Fjord Spa
Oslo Fjord Spa Yıl önce
love it
Aaliyah Lee
Aaliyah Lee 25 gün önce
There is actually no problem with aging. It comes naturally and it is beyond our control. However, we are the ones responsible on how to slow the aging process. Can you notice that many people in their 50s actually look like 30s. 70s look like 50s! Well… Growing old is no piece of cake, that is for certain. NMN and resveratrol are seen to affect health positively and do reverse aging. Since no healthcare company wants people to live a healthy life (how will they run their business if that happens.) I started taking the NMN by Vitruvin with 500mg and seeing very good results. Especially, NMN is boosting my energy levels very effectively. I also think the results might vary from person to person.
דניאל גליק
דניאל גליק Yıl önce
How I have never heard of it?Mind blow
Deepak Gaury
Deepak Gaury 3 yıl önce
Conversas Controversas
Conversas Controversas Yıl önce
Conversas Controversas
Conversas Controversas 21 gün önce
@Ana Niorba yes
Ana Niorba
Ana Niorba 21 gün önce
Conversas, are you all right?
Jeremy Anderson
Jeremy Anderson 6 aylar önce
Yeah save humans and animals too making becomes younger.
God 11 aylar önce
“There were no people born of the 19th century here today” The immortal dude in the room: *adding that quote to list of coincidences since he’s present*
Charles David
Charles David 8 aylar önce
As noted, there are multiple causes of aging. The first is due to thermodynamics and the increase in entropy that occurs in a system that uses energy to process information. There are just a few states for a living cell while there are almost an infinite number of states of death and decay. The second is due to the accumulation of damage that occurs when there is no proper repair. The body is excellent at healing when provided the resources to do so, but most people do not provide the proper resources. The most important resource is pulsed nutrition with periods of feasting and fasting in synchrony with one's neuro-endocrine cycles. This allows the body to clean house via the cellular mechanism of autophagy while activation of the sirtuins in the presence of high levels of NAD+ facilitate DNA repair, including restoring the telomeres. The re-feeding/feasting phase activates the stem cells to rejuvenate damaged cells, like the immune system, brain, and muscles thereby preventing the onset of frailty, autoimmune disorders, inflammation, and dementia. Also, maintaining proper methylation of one's DNA prevents endogenous virii from activating and causing harm. Receiving blood transfusions or vaccinations that are contaminated with retrovirii can also activate those endogenous virii. While treatment with retro-viral agents such as those used for the treatment of HIV (AZT) might help to fight off any activated retrovirii, there is no evidence that it can perform the other tasks needed to prevent frailty and the steady progression to death. Sorry, but that is not the fountain of youth.
MrMpalmer33 3 yıl önce
Examples please...
Ceasar Langley
Ceasar Langley 4 yıl önce
Dr Andrei Gudkov is both smart and funny at same time....I cracked up when he said the word "Alcohol"..lmao
Coinpicker 3 yıl önce
Aging cell damage sounds like effects of free-radicals.
One Two
One Two 4 yıl önce
There in an alternative theory, which suggests that it is the length of telomers that determines how healthy the dna and cells are. It clearly correlates to health of human body. Interestingly enough, part of that theory is that the telomers can loop back to the middle sections of dna and repair the sites that turn genes on and off. As telomers get too short to keep turned off genes in check, the "virus" genes turn on and mutate cells perhaps?
Michael Davidson
Michael Davidson 3 yıl önce
It's not an alternative theory. It's ANOTHER cause of aging, of which there are many. These include the accumulation of senecent cells and DNA damage from chemicals and radiation.
𝓓𝓻.𝓡𝓸𝓼𝓮 🌸
𝓓𝓻.𝓡𝓸𝓼𝓮 🌸 3 aylar önce
sarai wongkaew
sarai wongkaew 3 yıl önce
I am trying to learn about all chakra for absorbing energy of life from nature.I meant trees, water, wind, sun,wind. Particularly trees have energy of life. Meditation will promote young cells to all of lives.😁🌱💑 That why human should keep and increase pure nature .
Debbie Tudor
Debbie Tudor 10 aylar önce
Funny ending! Watch all of it!
Lucifer Morning Star
Lucifer Morning Star 3 aylar önce
I wish if we can stop aging i want fo stop aging at my age 18
Henry Aguila
Henry Aguila 2 yıl önce
I found a way to slow aging, through G meditation.
faismasterx 4 yıl önce
I quickly read the title as, "Can we stop arguing?"
Debbie Tudor
Debbie Tudor 7 aylar önce
Gabriel Incognito
Gabriel Incognito 3 yıl önce
Only if you accept that gender is on a spectrum.
valar 4 yıl önce
Harder question to answer :)
Jeremy Anderson
Jeremy Anderson 6 aylar önce
Stop, yes, delay Yes! Younger awesomeness.
Faizan Aylar önce
Marc Lapointe
Marc Lapointe 2 yıl önce
I'd be happy with 20% longer life assuming 100y life span that's 20 years
Cur Tseed
Cur Tseed 2 yıl önce
More like 20% longer youth.
Brian 2 yıl önce
Shanthi Thomas
Shanthi Thomas 4 yıl önce
Mirza Kadrić
Mirza Kadrić 2 yıl önce
So basically that ancient DNA virus trigger mammal evolution???
청ずらたん 3 aylar önce
FIVE years ago and we are still aging. They will still be talking about "stopping aging" in 30 years (well, probably different people, because AGING) and nothing will change. AGING is a FACT of life.
청ずらたん Aylar önce
@Iche That's a pretty long reach. I'm sure lots of Japanese people are conservative. So are many people everywhere. Europe has very strict regulations on biotechnology. The US has a large party opposed to abortion. I'm not sure the attitude towards "invasive" technological progress in Japan is more hostile than it is in US or Europe, but I would say that the idea of Japan as an advanced country which embraces new technology (which is the common stereotype) does have some omissions, such as the still widespread use of telefax and CD. Certainly I feel that society is more conservative than in the West. Whether you want to count biotechnology as falling into the domain of conservative or progressive attitudes in Japanese society is a difficult question that I don't know answer. Neither would I know about "weebs". I am 50 years old and not so familiar with online culture. But it's not so important what is society thinking. I am not so opposed to this technology. I personally don't see a need to take it (why want to live a long time in an old body and feeling unwell?) but I am not opposed to someone taking it if they want to. I'm just pessimist about it. Big difference - pessimist and conservative... In addition, allow another country stereotype: it is so common for Russians to have outlandish and freakish pseudoscience theory on a lot of things. It's like they never fact check with science and live in their own universe. The things this "scientist" is talking about - ancient virus DNA gets activated and so on - is not shared by ANY of the scientists working in the field. You can check Dr. Sinclair and also Altos Labs. They have very different ideas. Today, anyone can sell a crackpot self made theory as fact because someone lets them use TEDx microphone. The guy in the video is living in a fantasy world.
청ずらたん Aylar önce
@Iche Yes, I think so too. In the long future, people will be able to use this technology.
Iche Aylar önce
The problem is that you are BIOCONSERVATIVE. A lot of Japanese people or Weebs are conservative.
Iche Aylar önce
@청ずらたん They made progress, just saying.
Wilhelm Kiev
Wilhelm Kiev 3 yıl önce
At first I read this "can we stop arguing" lol
Shanthi Thomas
Shanthi Thomas 4 yıl önce
ENNERVOOL 3 aylar önce
Make a self-improving A.I and task it with finding inmortality
Muscular Chicken
Muscular Chicken Aylar önce
I'm sure that the scientists would have already done it if that was possible.
wabi sabi
wabi sabi Yıl önce
14:47 Exactly
Gabriel Litewski
Gabriel Litewski 3 aylar önce
Where do decide when I've had enough!?
NOUM 5 aylar önce
When I like the idea of living longer as much as the next guy, I don't think the Earth can support more people
NOUM 3 aylar önce
@Abdel Manzalawi I'm more onto a biological point of view of the universe, and we human can only survive by depending on biological diversity. And turns out, 99.9% of stuff that fills the observable universe are just dead rocks/gas/water... and life can't survive there. It's very optimistic to think that we can be as infinite as the universe but until our technology was able to terraform planets to make them habitable or turn any dead matter into something edible, I'm afraid we are stuck here on Earth for the time being, unless of course we all turn into robots lol
Abdel Manzalawi
Abdel Manzalawi 3 aylar önce
Hi there. Comparing to our sense of space, the universe is unlimited, the energy out there is also unlimited. The raw materials of living can manufacture to a point that it seems unlimited. We can manage to cultivate a trillion person civilization if we want to. Think about how much we've already achieved. With the right guidance, we can do an infinite wonders. Thnx, a sociology teacher 🍵
N Z Yıl önce
Who is here during the COVID-19 pandemic?
Donovan Yıl önce
Me, and COVID-19 reminds us of the importance of fighting against aging (especially against the aging of the immune system) because the elderly are the main victims of the virus.
Michael Shannon
Michael Shannon 2 yıl önce
Only time and boomers can stop us.
splash2350 2 aylar önce
20 % longer life is much tho ? isnt it ? or did i understand it wrong
Lord Voldemort
Lord Voldemort 2 yıl önce
Only I can live forever..!
Faizan Aylar önce
Wait and examine
J.Miller AA BA MSc
J.Miller AA BA MSc 2 yıl önce
KariahLuke MacChan
KariahLuke MacChan 2 yıl önce
Noah lived to 800 beat that! Sarah, Abraham’s wife was 100 when she became pregnant. Both didn’t need to fast. Beat that!
Ismaeel Mahmood
Ismaeel Mahmood 6 aylar önce
If humans managed to achieve biological immortality then we'd probably survive 9000 years before dying of causes such as car crashes. I watched a youtube video that said that and since that's not exactly a 'reliable' source I'd urge you to take with a many grains of salt. Still, a fascinating concept to dreamboat that one day may become reality in some form.
kkostadinof Yıl önce
Cool story bro!
Cur Tseed
Cur Tseed 2 yıl önce
Why aren't there any millenials aged human beings now? Shouldnt there be some type of Bible update every millenia just in case people need to be reassured?
darren dwyer
darren dwyer 4 yıl önce
3,000,000,000 or so dna 'bits'... divided by 100 years == 30,000,000 genetic sequences are decoded each year.... oh, it's 82,000 dna extractions per day...
Olesya Sen
Olesya Sen 5 yıl önce
can I get a couple of these drugs, please :)
Grin Wrath
Grin Wrath 5 aylar önce
Only RE5 Wesker has the solution (The right to become a god is mine)
compucentrum 3 yıl önce
All of the free lectures on slowing aging are meant to discourage you from prolonging your life. Eat foods that accelerate aging, wait and grow old. We have known since 1956 how to prolong life two to three times. But we will not tell anyone, certainly not for free.
compucentrum Yıl önce
@Absolute Unit - Let me ask you a question: How do you know people who take synthetic anti-aging chemicals? Are they young? No. For example, the Queen of England is 95 years old and her husband 99 years old. They are old. Those twice-life-prolonging drugs cause those who take them for 20 years to be 10 years younger than they are. That's simple math. E.g. he starts at 50 and at 70 looks 60. Just 10 years younger. Foods that accelerate aging are not as effective. Whoever eats them 50 years old looks 10 years older. There are a lot of such people.
Cur Tseed
Cur Tseed 2 yıl önce
Why wouldnt those "in the know" just show some samples of longer lifespan humans and charge everybody once it is proven in front of their eyes?
Ben Weir
Ben Weir 3 yıl önce
This comment makes no sense.
Christopher Ellis
Christopher Ellis 2 yıl önce
The good doctor is somewhat younger than me 🖤 yet I look younger than he . LXX 💱 XXL 💙 Senescent cells do not need some laboratory 🔬 concoction to be removed, because the natural bodily processes, if left to it, can process them. 💚 🧙‍♂️
Ismaeel Mahmood
Ismaeel Mahmood 6 aylar önce
Bro your profile pic looks atleast two decades older than him. And besides, humans have been leaving things to 'bodily processes' since we first walked the planet, its never stopped our aging yet, we have no choice but to intervene if we want any change. I'm not trying to offend tho, gl man.
Donovan Yıl önce
Except that this system is imperfect and sometimes it forgets certain senescent cells.
TheProRebel 00
TheProRebel 00 6 aylar önce
If we managed to pull this off and completely stop aging, then what about world population?
Abdel Manzalawi
Abdel Manzalawi 3 aylar önce
The universe has 2 trillion galaxies as far as we know. There is Unlimited number of planets out there.
jacob almeda
jacob almeda 2 yıl önce
S I 2 yıl önce
Live in space
Carl White
Carl White 10 aylar önce
Four years ago now. I don't see any publications on this. What progress has been made?
Søren Sloth
Søren Sloth 6 aylar önce
I recommend following the SENS foundation or David Sinclair for news on this topic.
Noe Morin
Noe Morin 4 yıl önce
chris silliker
chris silliker 6 aylar önce
24000 votes from one address in wisconsin wtf
RedT 3 yıl önce
Stop? No. Delay? Yes.
Jeremy Anderson
Jeremy Anderson 7 aylar önce
@Abdul R sorry
Jeremy Anderson
Jeremy Anderson 7 aylar önce
@Abdul R yes it’s bro it is possible and hope.
Kai ninja Thundermmando Poke
Kai ninja Thundermmando Poke 7 aylar önce
@Abdul R yes it is.
3301 Yıl önce
100 years ago we didn't had cars now we are weekly flying to space and created AI thats smarter than any human. I dont believe i know we can stop aging and maybe even in less than 50 years from now.
cluelesscastelino Yıl önce
Get ready to be disappointed
Fitzroy Armour
Fitzroy Armour 6 aylar önce
the fossils and geology prove All created as in Genesis
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